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Dna Replication And Repair Pdf Free

 
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MessagePosté le: Mer 5 Oct - 22:35 (2016)    Sujet du message: Dna Replication And Repair Pdf Free Répondre en citant




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Dna Replication And Repair Pdf Free

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The,,,correct,,,nucleotide,,,has,,,a,,,higher,,,affinity,,,for,,,the,,,moving,,,polymerase,,,than,,,does,,,the,,,incorrect,,,nucleotide,,,,because,,,only,,,the,,,correct,,,nucleotide,,,can,,,correctly,,,base-pair,,,with,,,the,,,template.,,,89–90),,,,it,,,does,,,not,,,occur,,,in,,,DNA,,,synthesis;,,,no,,,3′-to-5′,,,DNA,,,polymerase,,,has,,,ever,,,been,,,found.,,,The,,,major,,,types,,,of,,,proteins,,,that,,,act,,,at,,,a,,,DNA,,,replication,,,fork,,,are,,,illustrated,,,,showing,,,their,,,approximate,,,positions,,,on,,,the,,,DNA.,,,The,,,progress,,,of,,,the,,,eukaryotic,,,cell,,,through,,,the,,,cycle,,,is,,,controlled,,,by,,,cell,,,cycle,,,checkpoints.,,,However,,,,on,,,the,,,lagging-strand,,,template,,,,each,,,time,,,the,,,polymerase,,,reaches,,,the,,,5′,,,end,,,of,,,the,,,preceding,,,Okazaki,,,fragment,,,,the,,,polymerase,,,is,,,released;,,,this,,,polymerase,,,molecule,,,then,,,associates,,,with,,,a,,,new,,,clamp,,,that,,,is,,,assembled,,,on,,,the,,,RNA,,,primer,,,of,,,the,,,next,,,Okazaki,,,fragment,,,(Figure,,,5-20).,,,In,,,addition,,,,their,,,cooperative,,,binding,,,coats,,,and,,,straightens,,,out,,,the,,,regions,,,of,,,single-stranded,,,DNA,,,on,,,the,,,lagging-strand,,,template,,,,thereby,,,preventing,,,the,,,formation,,,of,,,the,,,short,,,hairpin,,,helices,,,that,,,readily,,,form,,,in,,,single-strand,,,DNA,,,(Figures,,,5-17,,,and,,,5-18).,,,

Annual,,,,Review,,,,of,,,,Biochemistry.,,,,ISBN0-7167-3051-0.,,,,PLoS,,Biology.,,W.H.,,,The,,,,nucleotides,,,,on,,,,a,,,,single,,,,strand,,,,can,,,,therefore,,,,be,,,,used,,,,to,,,,reconstruct,,,,nucleotides,,,,on,,,,a,,,,newly,,,,synthesized,,,,partner,,,,strand.[4].,,,,Figure,,,5-19The,,,regulated,,,sliding,,,clamp,,,that,,,holds,,,DNA,,,polymerase,,,on,,,the,,,DNA.,,,access-date=,,requires,,url=,,(help),,^,,McCarthy,,,David;,,Minner,,,Charles;,,Bernstein,,,Harris;,,Bernstein,,,Carol,,(October,,1976).,,Ligase,,works,,to,,fill,,these,,nicks,,in,,,thus,,completing,,the,,newly,,replicated,,DNA,,molecule.,,In,,,,various,,,,bacterial,,,,species,,,,,this,,,,is,,,,named,,,,the,,,,DNA,,,,replication,,,,terminus,,,,site-binding,,,,protein,,,,,or,,,,Ter,,,,protein.,,,,Thus,,,,,any,,,,enzyme,,,,that,,,,primes,,,,the,,,,synthesis,,,,of,,,,Okazaki,,,,fragments,,,,will,,,,of,,,,necessity,,,,make,,,,a,,,,relatively,,,,inaccurate,,,,copy,,,,(at,,,,least,,,,1,,,,error,,,,in,,,,105).,,,,

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